Flow velocity of cutaneous lymphatic capillaries in patients with primary lymphedema.
Identifieur interne : 012D26 ( Main/Exploration ); précédent : 012D25; suivant : 012D27Flow velocity of cutaneous lymphatic capillaries in patients with primary lymphedema.
Auteurs : M. Fischer [Suisse] ; U. Costanzo ; U. Hoffmann ; A. Bollinger ; U K FranzeckSource :
- International journal of microcirculation, clinical and experimental [ 0167-6865 ]
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Dextrane, Femelle, Fluorescéine-5-isothiocyanate (analogues et dérivés), Humains, Injections lymphatiques, Lymphe (), Lymphe (physiologie), Lymphoedème (physiopathologie), Microscopie de fluorescence, Mâle, Phénomènes physiologiques de la peau, Produits de contraste, Sujet âgé, Système lymphatique (), Système lymphatique (physiologie), Vidéomicroscopie.
- MESH :
- analogues et dérivés : Fluorescéine-5-isothiocyanate.
- physiologie : Lymphe, Système lymphatique.
- physiopathologie : Lymphoedème.
- Adulte, Adulte d'âge moyen, Dextrane, Femelle, Humains, Injections lymphatiques, Lymphe, Microscopie de fluorescence, Mâle, Phénomènes physiologiques de la peau, Produits de contraste, Sujet âgé, Système lymphatique, Vidéomicroscopie.
English descriptors
- KwdEn :
- Adult, Aged, Contrast Media, Dextrans, Female, Fluorescein-5-isothiocyanate (analogs & derivatives), Humans, Injections, Intralymphatic, Lymph (chemistry), Lymph (physiology), Lymphatic System (drug effects), Lymphatic System (physiology), Lymphedema (physiopathology), Male, Microscopy, Fluorescence, Microscopy, Video, Middle Aged, Skin Physiological Phenomena.
- MESH :
- chemical , analogs & derivatives : Fluorescein-5-isothiocyanate.
- chemical : Contrast Media, Dextrans.
- chemistry : Lymph.
- drug effects : Lymphatic System.
- physiology : Lymph, Lymphatic System.
- physiopathology : Lymphedema.
- Adult, Aged, Female, Humans, Injections, Intralymphatic, Male, Microscopy, Fluorescence, Microscopy, Video, Middle Aged, Skin Physiological Phenomena.
Abstract
For the first time measurements of lymph flow velocities in cutaneous microlymphatics of patients with lymphedema were performed and compared with healthy subjects. Flow velocity in single lymphatic skin capillaries was measured using fluorescence video microscopy after subepidermal microinjection of FITC-dextran 150,000 in 15 healthy volunteers and 16 patients with primary lymphedema. Initial filling of the lymphatic capillary network was fast with significantly higher mean velocities in patients with primary lymphedema than in healthy controls (890 +/- 43 vs. 550 +/- 390 microns/s, p < 0.05). The resting velocities were not significantly different between controls and patients (10.3 +/- 4.1 vs. 16.6 +/- 13.9 microns). In 12 out of the 16 lymphedema patients cutaneous backflow of the fluorescent contrast medium from deeper invisible lymphatics was observed. In 4 of these patients rhythmic reflux with a mean frequency of 1.4 +/- 0.5 cycles/min was measured by video densitometry in microlymphatics with a significantly (p < 0.01) enhanced diameter. Mean flow velocity (Vp) in these precollectors was significantly increased compared to the resting velocities (p < 0.01). On the basis of these results the hypothesis is advanced that rhythmic cutaneous backflow originates from intrinsic contractions of deeper lymph collector segments and is transmitted to the superficial microlymphatics through incompetent connecting channels. This newly recognized mechanism appears to be an important factor for the pathophysiology of lymphedema.
PubMed: 9272465
Affiliations:
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Le document en format XML
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Bollinger</name></author><author><name sortKey="Franzeck, U K" sort="Franzeck, U K" uniqKey="Franzeck U" first="U K" last="Franzeck">U K Franzeck</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="????"><PubDate><MedlineDate>1997 May-Jun</MedlineDate></PubDate></date><idno type="RBID">pubmed:9272465</idno><idno type="pmid">9272465</idno><idno type="wicri:Area/PubMed/Corpus">005007</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">005007</idno><idno type="wicri:Area/PubMed/Curation">005007</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">005007</idno><idno type="wicri:Area/PubMed/Checkpoint">005007</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">005007</idno><idno type="wicri:Area/Ncbi/Merge">00BA46</idno><idno type="wicri:Area/Ncbi/Curation">00BA46</idno><idno type="wicri:Area/Ncbi/Checkpoint">00BA46</idno><idno type="wicri:doubleKey">0167-6865::Fischer M:flow:velocity:of</idno><idno type="wicri:Area/Main/Merge">013F45</idno><idno type="wicri:Area/Main/Curation">012D26</idno><idno type="wicri:Area/Main/Exploration">012D26</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Flow velocity of cutaneous lymphatic capillaries in patients with primary lymphedema.</title><author><name sortKey="Fischer, M" sort="Fischer, M" uniqKey="Fischer M" first="M" last="Fischer">M. Fischer</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, University Hospital, Zurich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Medicine, University Hospital, Zurich</wicri:regionArea><wicri:noRegion>Zurich</wicri:noRegion></affiliation></author><author><name sortKey="Costanzo, U" sort="Costanzo, U" uniqKey="Costanzo U" first="U" last="Costanzo">U. Costanzo</name></author><author><name sortKey="Hoffmann, U" sort="Hoffmann, U" uniqKey="Hoffmann U" first="U" last="Hoffmann">U. Hoffmann</name></author><author><name sortKey="Bollinger, A" sort="Bollinger, A" uniqKey="Bollinger A" first="A" last="Bollinger">A. Bollinger</name></author><author><name sortKey="Franzeck, U K" sort="Franzeck, U K" uniqKey="Franzeck U" first="U K" last="Franzeck">U K Franzeck</name></author></analytic><series><title level="j">International journal of microcirculation, clinical and experimental</title><idno type="ISSN">0167-6865</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Contrast Media</term><term>Dextrans</term><term>Female</term><term>Fluorescein-5-isothiocyanate (analogs & derivatives)</term><term>Humans</term><term>Injections, Intralymphatic</term><term>Lymph (chemistry)</term><term>Lymph (physiology)</term><term>Lymphatic System (drug effects)</term><term>Lymphatic System (physiology)</term><term>Lymphedema (physiopathology)</term><term>Male</term><term>Microscopy, Fluorescence</term><term>Microscopy, Video</term><term>Middle Aged</term><term>Skin Physiological Phenomena</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Dextrane</term><term>Femelle</term><term>Fluorescéine-5-isothiocyanate (analogues et dérivés)</term><term>Humains</term><term>Injections lymphatiques</term><term>Lymphe ()</term><term>Lymphe (physiologie)</term><term>Lymphoedème (physiopathologie)</term><term>Microscopie de fluorescence</term><term>Mâle</term><term>Phénomènes physiologiques de la peau</term><term>Produits de contraste</term><term>Sujet âgé</term><term>Système lymphatique ()</term><term>Système lymphatique (physiologie)</term><term>Vidéomicroscopie</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Fluorescein-5-isothiocyanate</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Contrast Media</term><term>Dextrans</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Fluorescéine-5-isothiocyanate</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Lymph</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Lymphatic System</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Lymphe</term><term>Système lymphatique</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Lymph</term><term>Lymphatic System</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Lymphoedème</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Injections, Intralymphatic</term><term>Male</term><term>Microscopy, Fluorescence</term><term>Microscopy, Video</term><term>Middle Aged</term><term>Skin Physiological Phenomena</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Dextrane</term><term>Femelle</term><term>Humains</term><term>Injections lymphatiques</term><term>Lymphe</term><term>Microscopie de fluorescence</term><term>Mâle</term><term>Phénomènes physiologiques de la peau</term><term>Produits de contraste</term><term>Sujet âgé</term><term>Système lymphatique</term><term>Vidéomicroscopie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">For the first time measurements of lymph flow velocities in cutaneous microlymphatics of patients with lymphedema were performed and compared with healthy subjects. Flow velocity in single lymphatic skin capillaries was measured using fluorescence video microscopy after subepidermal microinjection of FITC-dextran 150,000 in 15 healthy volunteers and 16 patients with primary lymphedema. Initial filling of the lymphatic capillary network was fast with significantly higher mean velocities in patients with primary lymphedema than in healthy controls (890 +/- 43 vs. 550 +/- 390 microns/s, p < 0.05). The resting velocities were not significantly different between controls and patients (10.3 +/- 4.1 vs. 16.6 +/- 13.9 microns). In 12 out of the 16 lymphedema patients cutaneous backflow of the fluorescent contrast medium from deeper invisible lymphatics was observed. In 4 of these patients rhythmic reflux with a mean frequency of 1.4 +/- 0.5 cycles/min was measured by video densitometry in microlymphatics with a significantly (p < 0.01) enhanced diameter. Mean flow velocity (Vp) in these precollectors was significantly increased compared to the resting velocities (p < 0.01). On the basis of these results the hypothesis is advanced that rhythmic cutaneous backflow originates from intrinsic contractions of deeper lymph collector segments and is transmitted to the superficial microlymphatics through incompetent connecting channels. This newly recognized mechanism appears to be an important factor for the pathophysiology of lymphedema.</div></front></TEI><affiliations><list><country><li>Suisse</li></country></list><tree><noCountry><name sortKey="Bollinger, A" sort="Bollinger, A" uniqKey="Bollinger A" first="A" last="Bollinger">A. Bollinger</name><name sortKey="Costanzo, U" sort="Costanzo, U" uniqKey="Costanzo U" first="U" last="Costanzo">U. Costanzo</name><name sortKey="Franzeck, U K" sort="Franzeck, U K" uniqKey="Franzeck U" first="U K" last="Franzeck">U K Franzeck</name><name sortKey="Hoffmann, U" sort="Hoffmann, U" uniqKey="Hoffmann U" first="U" last="Hoffmann">U. Hoffmann</name></noCountry><country name="Suisse"><noRegion><name sortKey="Fischer, M" sort="Fischer, M" uniqKey="Fischer M" first="M" last="Fischer">M. Fischer</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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